| Open dos EUA | 08/29 16:00 | 24 | [6] Alexander Zverev v Frances Tiafoe [45] | 6-3,3-6,6-2,2-6,6-3 | |
| Open dos EUA | 08/27 21:45 | 23 | [79] Ivo Karlovic v Frances Tiafoe [45] | Retired | |
| ATP - Winston-Salem | 08/23 19:10 | 27 | [52] Frances Tiafoe v Hubert Hurkacz [41] | 6-4,6-7,1-6 | |
| ATP - Winston-Salem | 08/22 00:30 | 26 | [51] Filip Krajinovic v Frances Tiafoe [52] | Retired | |
| ATP - Winston-Salem | 08/21 00:35 | 25 | [74] Jeremy Chardy v Frances Tiafoe [52] | Retired | |
| ATP - Cincinnati | 08/14 23:00 | 25 | [52] Frances Tiafoe v Roberto B-Agut [11] | 3-6,6-3,1-6 | |
| ATP - Cincinnati | 08/13 16:15 | 24 | [15] Gael Monfils v Frances Tiafoe [52] | 6-7,3-6 | |
| ATP - Washington | 08/01 22:25 | 26 | [40] Frances Tiafoe v Daniil Medvedev [10] | 2-6,5-7 | |
| ATP - Washington | 07/30 20:30 | 25 | [40] Frances Tiafoe v Alexander Bublik [72] | 6-1,7-6 | |
| ATP - Atlanta | 07/23 20:05 | 25 | [106] Bernard Tomic v Frances Tiafoe [41] | 4-6,6-3,7-6 | |
| Wimbledon | 07/02 15:40 | 23 | [38] Frances Tiafoe v Fabio Fognini [10] | 7-5,4-6,3-6,6-4,4-6 | |
| ATP - Queens | 06/17 13:40 | 25 | [191] Nicolas Mahut v Frances Tiafoe [36] | 6-3,7-6 | |
| ATP - Hertogenbosch | 06/12 14:00 | 26 | [62] Jordan Thompson v Frances Tiafoe [35] | 6-3,6-2 | |
| ATP - Hertogenbosch | 06/10 16:55 | 25 | [71] Joao Sousa v Frances Tiafoe [35] | 2-6,6-7 | |
| Open de França | 05/27 09:00 | 23 | [60] Filip Krajinovic v Frances Tiafoe [34] | 6-2,4-6,6-3,3-6,6-0 | |
| ATP - Roma | 05/14 11:00 | 24 | [34] Frances Tiafoe v Joao Sousa [72] | 3-6,7-6,6-7 | |
| ATP - Madrid | 05/09 18:00 | 26 | [37] Frances Tiafoe v Rafael Nadal [2] | 3-6,4-6 | |
| ATP - Madrid | 05/08 10:00 | 25 | [37] Frances Tiafoe v Philipp Kohlschreiber [50] | 6-4,3-6,6-3 | |
| ATP - Madrid | 05/06 11:50 | 24 | [17] Nikoloz Basilashvili v Frances Tiafoe [37] | 7-6,3-6,4-6 | |
| ATP - Estoril | 05/03 19:50 | 27 | [31] Frances Tiafoe v Pablo Cuevas [67] | 0-6,7-6,2-6 | |
| ATP - Estoril | 05/02 18:40 | 26 | [31] Frances Tiafoe v Yoshihito Nishioka [71] | 2-6,6-3,7-6 | |
| ATP - Estoril | 04/30 17:00 | 25 | [31] Frances Tiafoe v Mikhail Kukushkin [40] | 6-3,7-5 | |
| ATP - Barcelona | 04/23 14:10 | 25 | [57] Jaume Munar v Frances Tiafoe [30] | 6-4,6-3 | |
| ATP - Miami | 03/28 22:30 | 27 | [23] Denis Shapovalov v Frances Tiafoe [34] | 6-7,6-4,6-2 | |
| ATP - Miami | 03/26 22:50 | 26 | [20] David Goffin v Frances Tiafoe [34] | 5-7,6-7 | |
| ATP - Miami | 03/25 23:30 | 25 | [34] Frances Tiafoe v David Ferrer [155] | 5-7,6-3,6-3 | |
| ATP - Miami | 03/23 23:40 | 24 | [34] Frances Tiafoe v Miomir Kecmanovic [95] | 7-6,7-6 | |
| ATP - Indian Wells | 03/09 04:30 | 23 | [86] Nicolas Jarry v Frances Tiafoe [35] | 6-4,4-6,7-5 | |
| ATP - Acapulco | 02/28 00:00 | 26 | [34] Frances Tiafoe v Mackenzie McDonald [71] | 7-6,5-7,3-6 | |
| ATP - Acapulco | 02/26 04:35 | 25 | [34] Frances Tiafoe v Jordan Thompson [79] | 3-6,6-4,6-3 |