Léodegario Santa Cruz (born 10 August 1988) is a Mexican professional boxer. He is a four-weight world champion, having held the IBF bantamweight title from 2012 to 2013, the WBC super bantamweight title from 2013 to 2015, the WBA (Super) featherweight title twice between 2015 and 2022, and the WBA (Super) super featherweight title from 2019 to 2020.
In January 2018, he reached a peak pound for pound ranking of sixth by the Transnational Boxing Rankings Board.
As of April 2021, he is ranked as the world's fourth best active featherweight by BoxRec.