[12] Leyton Orient 1-3 Tranmere [5] 2021-02-27 15:00
Estádio: Estádio Matchroom Round: 32
Juiz: Antony Coggins Home Manager: Ross Embleton Away Manager: Keith Hill
Head to Head
| Inglaterra - League Two | 2020/10/20 18:00 | Tranmere v Leyton Orient | W | 0-1 |
| Inglaterra - National League | 2018/02/10 15:00 | Leyton Orient v Tranmere | D | 1-1 |
| Inglaterra - National League | 2017/10/04 18:45 | Tranmere v Leyton Orient | L | 2-1 |
Home History
| Inglaterra - League Two | 2021/02/23 19:00 | Bradford v Leyton Orient | L | 1-0 |
| Inglaterra - League Two | 2021/02/20 15:00 | Leyton Orient v Port Vale | D | 1-1 |
| Inglaterra - League Two | 2021/02/06 15:00 | Leyton Orient v Colchester | D | 0-0 |
| Inglaterra - League Two | 2021/02/02 19:00 | Crawley Town v Leyton Orient | D | 0-0 |
| Inglaterra - League Two | 2021/01/30 15:00 | Bolton v Leyton Orient | L | 2-0 |
| Inglaterra - League Two | 2021/01/23 15:00 | Leyton Orient v Forest Green | L | 0-1 |
| Inglaterra - League Two | 2021/01/16 15:00 | Leyton Orient v Morecambe | W | 2-0 |
| Inglaterra - League Two | 2021/01/02 15:00 | Leyton Orient v Salford City | W | 1-0 |
Away History
| Inglaterra - League Two | 2021/02/23 19:00 | Carlisle v Tranmere | W | 2-3 |
| Inglaterra - League Two | 2021/02/20 15:00 | Tranmere v Oldham | D | 2-2 |
| Inglaterra - EFL Trophy | 2021/02/16 18:00 | Oxford Utd v Tranmere | W | 0-2 |
| Inglaterra - League Two | 2021/02/09 19:00 | Tranmere v Stevenage | L | 0-1 |
| Inglaterra - League Two | 2021/02/06 15:00 | Tranmere v Port Vale | W | 3-1 |
| Inglaterra - EFL Trophy | 2021/02/02 19:00 | Tranmere v Peterborough | W | 2-1 |
| Inglaterra - League Two | 2021/01/30 15:00 | Morecambe v Tranmere | W | 0-1 |
| Inglaterra - League Two | 2021/01/26 19:00 | Tranmere v Harrogate Town | W | 3-2 |