[1] Cruz Azul 3-2 Atlético San Luís [16] 2021-04-24 22:00
Estádio: Estadio Azteca Round: 16
Juiz: Luis Enrique Santander Aguirre Home Manager: Armando Gonzalez Away Manager: Leonel Rocco
Head to Head
| México - Liga MX | 2020/08/24 00:35 | Atlético San Luís v Cruz Azul | W | 1-3 |
| México - Liga MX | 2020/01/18 01:00 | Atlético San Luís v Cruz Azul | L | 2-1 |
| México - Liga MX | 2019/11/24 01:00 | Cruz Azul v Atlético San Luís | W | 3-1 |
Home History
| México - Liga MX | 2021/04/18 02:05 | Club América v Cruz Azul | D | 1-1 |
| CONCACAF - Taça dos Campeões | 2021/04/14 02:00 | Cruz Azul v Arcahaie FC | W | 8-0 |
| México - Liga MX | 2021/04/11 00:00 | Cruz Azul v Chivas Guadalajara | W | 1-0 |
| CONCACAF - Taça dos Campeões | 2021/04/07 02:00 | Arcahaie FC v Cruz Azul | D | 0-0 |
| México - Liga MX | 2021/04/03 03:30 | Juárez FC v Cruz Azul | W | 0-1 |
| México - Liga MX | 2021/03/21 01:00 | Cruz Azul v Atlas | W | 3-2 |
| México - Liga MX | 2021/03/14 03:00 | Cruz Azul v Monterrey | W | 1-0 |
| México - Liga MX | 2021/03/08 03:00 | Pumas v Cruz Azul | W | 0-1 |
Away History
| México - Liga MX | 2021/04/17 22:00 | Atlético San Luís v Puebla | L | 1-4 |
| México - Liga MX | 2021/04/10 02:30 | Juárez FC v Atlético San Luís | L | 2-1 |
| México - Liga MX | 2021/04/04 03:06 | Monterrey v Atlético San Luís | L | 2-0 |
| México - Liga MX | 2021/03/20 23:00 | Atlético San Luís v Pumas | L | 0-1 |
| México - Liga MX | 2021/03/15 00:00 | Querétaro v Atlético San Luís | L | 2-1 |
| México - Liga MX | 2021/03/06 01:30 | Atlético San Luís v Toluca | D | 0-0 |
| México - Liga MX | 2021/03/02 23:00 | Atlas v Atlético San Luís | L | 3-1 |
| México - Liga MX | 2021/02/26 03:00 | Atlético San Luís v Tigres UANL | D | 2-2 |