Estádio: Terreno Tubby Raymond no Estádio Delaware Round: 1
Home Manager: Danny Rocco Away Manager: Mike London
| NCAAF | 2021/10/30 17:00 | William & Mary v Villanova | W | 31-18 |
| NCAAF | 2021/10/23 19:30 | Towson v William & Mary | W | 14-40 |
| NCAAF | 2021/10/16 16:00 | William & Mary v Maine | L | 16-27 |
| NCAAF | 2021/10/09 19:30 | Albany v William & Mary | W | 24-31 |
| NCAAF | 2021/09/25 18:00 | William & Mary v Elon | W | 34-31 |
| NCAAF | 2021/09/18 17:00 | William & Mary v Colgate | W | 27-7 |
| NCAAF | 2021/09/11 22:00 | Lafayette v William & Mary | W | 3-24 |
| NCAAF | 2021/09/04 23:30 | William & Mary v Virginia | L | 0-43 |
| NCAAF | 2021/10/30 17:00 | Utah Tech v Delaware | W | 10-17 |
| NCAAF | 2021/10/23 19:00 | James Madison v Delaware | L | 22-10 |
| NCAAF | 2021/10/16 19:30 | Delaware v Stony Brook | L | 17-34 |
| NCAAF | 2021/10/09 17:00 | Delaware v Rhode Island | L | 15-22 |
| NCAAF | 2021/10/02 19:00 | Albany v Delaware | W | 15-20 |
| NCAAF | 2021/09/18 19:30 | Delaware v Rutgers | L | 13-45 |
| NCAAF | 2021/09/11 22:00 | St.Francis (PA) v Delaware | W | 10-27 |
| NCAAF | 2021/09/02 23:00 | Delaware v Maine | W | 34-24 |