[14] BUF Sabres 3-1 OTT Senators [15] 2022-01-19 00:00
Estádio: Centro Tire do Canadá
Home Manager: Away Manager: Don Granato
Head to Head
| NHL | 2020/02/19 00:30 | BUF Sabres v OTT Senators | L | 4-7 |
| NHL | 2020/01/29 00:00 | OTT Senators v BUF Sabres | L | 5-2 |
| NHL | 2019/12/24 00:30 | BUF Sabres v OTT Senators | L | 1-3 |
| NHL | 2019/11/17 00:00 | OTT Senators v BUF Sabres | W | 2-4 |
| NHL | 2019/04/04 23:00 | OTT Senators v BUF Sabres | W | 2-5 |
| NHL | 2019/03/26 23:30 | BUF Sabres v OTT Senators | L | 0-4 |
| NHL | 2018/11/03 18:00 | OTT Senators v BUF Sabres | W | 2-9 |
| NHL | 2018/11/01 23:30 | BUF Sabres v OTT Senators | L | 2-4 |
Home History
| NHL | 2022/01/17 18:00 | DET Red Wings v BUF Sabres | L | 3-2 |
| NHL | 2022/01/16 00:00 | BUF Sabres v DET Red Wings | L | 0-4 |
| NHL | 2022/01/14 01:00 | BUF Sabres v NAS Predators | W | 4-1 |
| NHL | 2022/01/12 00:00 | TB Lightning v BUF Sabres | L | 6-1 |
| NHL | 2022/01/07 00:00 | SJ Sharks v BUF Sabres | L | 3-2 |
| NHL | 2022/01/01 18:00 | BUF Sabres v BOS Bruins | L | 3-4 |
| NHL | 2021/12/31 00:30 | BUF Sabres v NY Islanders | L | 1-4 |
| NHL | 2021/12/30 00:00 | NJ Devils v BUF Sabres | L | 4-3 |
Away History
| NHL | 2022/01/16 03:00 | OTT Senators v EDM Oilers | W | 6-4 |
| NHL | 2022/01/14 02:00 | OTT Senators v CAL Flames | W | 4-1 |
| NHL | 2022/01/02 00:00 | OTT Senators v TOR Maple Leafs | L | 0-6 |
| NHL | 2021/12/19 00:00 | OTT Senators v PHI Flyers | L | 3-4 |
| NHL | 2021/12/17 00:00 | OTT Senators v TB Lightning | L | 1-2 |
| NHL | 2021/12/15 00:00 | OTT Senators v FLA Panthers | W | 8-2 |
| NHL | 2021/12/11 18:00 | TB Lightning v OTT Senators | W | 0-4 |
| NHL | 2021/12/08 00:00 | NY Islanders v OTT Senators | L | 5-3 |