[4] Atlas 2-1 Santos Laguna [17] 2022-02-07 00:00
Estádio: Estádio Jalisco Round: 4
Juiz: Jorge Perez Home Manager: Diego Martin Cocca Away Manager: Pedro Caixinha
Head to Head
| México - Liga MX | 2021/08/19 00:00 | Santos Laguna v Atlas | D | 1-1 |
| México - Liga MX | 2021/02/06 23:00 | Atlas v Santos Laguna | D | 1-1 |
| México - Liga MX | 2020/08/17 00:06 | Santos Laguna v Atlas | D | 0-0 |
| México - Liga MX | 2020/03/02 00:45 | Santos Laguna v Atlas | L | 1-0 |
| México - Liga MX | 2019/08/03 02:00 | Atlas v Santos Laguna | L | 1-2 |
| México - Liga MX | 2019/03/30 03:00 | Atlas v Santos Laguna | W | 1-0 |
| México - Liga MX | 2018/10/06 00:00 | Santos Laguna v Atlas | L | 3-1 |
| México - Liga MX | 2018/03/31 03:00 | Atlas v Santos Laguna | W | 3-2 |
Home History
| México - Liga MX | 2022/01/23 03:00 | Club América v Atlas | W | 0-2 |
| México - Liga MX | 2022/01/20 03:00 | Club León v Atlas | D | 1-1 |
| México - Liga MX | 2022/01/15 23:00 | Atlas v Atlético San Luís | W | 1-0 |
| México - Liga MX | 2021/12/13 02:15 | Atlas v Club León | W | 5-3 |
| México - Liga MX | 2021/12/10 03:00 | Club León v Atlas | L | 3-2 |
| México - Liga MX | 2021/12/06 01:00 | Atlas v Pumas | L | 0-1 |
| México - Liga MX | 2021/12/03 03:00 | Pumas v Atlas | W | 0-1 |
| México - Liga MX | 2021/11/28 03:05 | Atlas v Monterrey | D | 1-1 |
Away History
| Europa - Amigáveis | 2022/01/29 02:00 | Mazatlán FC v Santos Laguna | L | 2-1 |
| México - Liga MX | 2022/01/24 01:00 | Santos Laguna v Necaxa | L | 1-4 |
| México - Liga MX | 2022/01/16 18:00 | Toluca v Santos Laguna | L | 3-1 |
| México - Liga MX | 2022/01/13 02:06 | Santos Laguna v Tigres UANL | D | 1-1 |
| México - Liga MX | 2021/11/29 00:00 | Tigres UANL v Santos Laguna | L | 1-0 |
| México - Liga MX | 2021/11/26 03:05 | Santos Laguna v Tigres UANL | W | 2-1 |
| México - Liga MX | 2021/11/21 01:00 | Santos Laguna v Atlético San Luís | W | 2-0 |
| México - Liga MX | 2021/11/08 01:06 | Santos Laguna v Atlético San Luís | D | 0-0 |