[16] Club América 1-3 Pachuca [4] 2022-02-20 22:00
Estádio: Estadio Azteca Round: 6
Juiz: Diego Montano Robles Home Manager: Santiago Solari Away Manager: Guillermo Almada
Head to Head
| México - Liga MX | 2021/09/29 02:05 | Pachuca v Club América | D | 1-1 |
| México - Liga MX | 2021/05/17 01:05 | Club América v Pachuca | W | 4-2 |
| México - Liga MX | 2021/05/14 00:00 | Pachuca v Club América | L | 3-1 |
| México - Liga MX | 2021/02/28 01:00 | Club América v Pachuca | W | 2-0 |
| México - Liga MX | 2020/07/28 01:00 | Pachuca v Club América | W | 1-2 |
| México - Liga MX | 2019/08/28 02:00 | Club América v Pachuca | D | 1-1 |
| Taça do México | 2019/02/27 03:15 | Club América v Pachuca | W | 5-2 |
| México - Liga MX | 2019/01/20 01:00 | Club América v Pachuca | W | 3-0 |
Home History
| México - Liga MX | 2022/02/17 01:00 | Mazatlán FC v Club América | L | 2-1 |
| México - Liga MX | 2022/02/13 03:00 | Santos Laguna v Club América | W | 2-3 |
| México - Liga MX | 2022/02/06 01:00 | Club América v Atlético San Luís | L | 2-3 |
| México - Liga MX | 2022/01/23 03:00 | Club América v Atlas | L | 0-2 |
| México - Liga MX | 2022/01/08 03:00 | Puebla v Club América | D | 1-1 |
| México - Liga MX | 2021/11/28 01:00 | Club América v Pumas | L | 1-3 |
| México - Liga MX | 2021/11/25 01:00 | Pumas v Club América | D | 0-0 |
| México - Liga MX | 2021/11/07 01:00 | Club América v Monterrey | D | 0-0 |
Away History
| México - Liga MX | 2022/02/15 03:00 | Pachuca v Querétaro | D | 2-2 |
| México - Liga MX | 2022/02/05 23:00 | Necaxa v Pachuca | W | 1-3 |
| México - Liga MX | 2022/01/23 01:00 | Club León v Pachuca | L | 2-1 |
| México - Liga MX | 2022/01/16 23:00 | Pachuca v Chivas Guadalajara | W | 2-1 |
| México - Liga MX | 2022/01/07 03:00 | Atlético San Luís v Pachuca | W | 0-2 |
| México - Liga MX | 2021/11/07 03:06 | Tijuana v Pachuca | L | 3-2 |
| México - Liga MX | 2021/11/04 01:00 | Pachuca v Atlético San Luís | D | 0-0 |
| México - Liga MX | 2021/10/31 00:06 | Pachuca v Pumas | D | 1-1 |