[10] Club América 2-0 Club León [11] 2022-04-21 02:00
Estádio: Estadio Azteca Round: 15
Juiz: Diego Montano Robles Home Manager: Fernando Ortiz Away Manager: Ariel Holan
Head to Head
| México - Liga MX | 2021/08/29 02:00 | Club León v Club América | D | 1-1 |
| México - Liga MX | 2021/03/07 01:00 | Club América v Club León | W | 2-1 |
| México - Liga MX | 2020/10/20 02:00 | Club León v Club América | L | 3-2 |
| México - Liga MX | 2019/07/28 00:00 | Club León v Club América | D | 0-0 |
| México - Liga MX | 2019/05/20 01:06 | Club León v Club América | W | 0-1 |
| México - Liga MX | 2019/05/17 01:30 | Club América v Club León | L | 0-1 |
| México - Liga MX | 2019/02/10 01:00 | Club América v Club León | L | 0-3 |
| México - Liga MX | 2018/08/23 00:00 | Club León v Club América | L | 2-0 |
Home History
| México - Liga MX | 2022/04/16 02:06 | Tijuana v Club América | W | 1-3 |
| México - Liga MX | 2022/04/10 02:00 | Club América v Juárez FC | W | 3-0 |
| México - Liga MX | 2022/04/03 01:00 | Necaxa v Club América | W | 0-1 |
| América - Amigáveis | 2022/03/24 01:02 | Club América v Tigres UANL | L | 1-2 |
| México - Liga MX | 2022/03/20 23:00 | Club América v Toluca | W | 3-0 |
| México - Liga MX | 2022/03/13 03:00 | Chivas Guadalajara v Club América | D | 0-0 |
| México - Liga MX | 2022/03/06 01:06 | Monterrey v Club América | L | 2-1 |
| México - Liga MX | 2022/03/02 03:00 | Club América v Querétaro | D | 1-1 |
Away History
| México - Liga MX | 2022/04/16 22:00 | Club León v Puebla | L | 0-1 |
| México - Liga MX | 2022/04/09 22:00 | Atlético San Luís v Club León | L | 2-0 |
| México - Liga MX | 2022/04/03 22:00 | Club León v Querétaro | D | 1-1 |
| México - Liga MX | 2022/03/21 03:00 | Mazatlán FC v Club León | W | 1-2 |
| CONCACAF - Taça dos Campeões | 2022/03/18 00:30 | Club León v Seattle Sounders | D | 1-1 |
| México - Liga MX | 2022/03/12 23:00 | Club León v Tigres UANL | L | 0-3 |
| CONCACAF - Taça dos Campeões | 2022/03/09 03:00 | Seattle Sounders v Club León | L | 3-0 |
| México - Liga MX | 2022/03/05 03:00 | Juárez FC v Club León | W | 0-1 |