| Uruguai - Liga de Reservas | 2022/05/02 18:00 | Defensor Sporting - Reservas v Atlético Fénix - Reservas | L | 0-2 |
| Uruguai - Liga de Reservas | 2022/04/05 19:00 | Defensor Sporting - Reservas v Club Atlético River Plate - Reservas | L | 0-2 |
| Uruguai - Liga de Reservas | 2022/03/29 19:00 | Boston River - Reservas v Defensor Sporting - Reservas | D | 1-1 |
| Uruguai - Liga de Reservas | 2022/03/22 18:00 | Defensor Sporting - Reservas v Club Plaza Colonia de Deportes - Reservas | W | 3-0 |
| Uruguai - Liga de Reservas | 2022/03/15 19:30 | Montevideo Wanderers - Reservas v Defensor Sporting - Reservas | L | 3-1 |
| Uruguai - Liga de Reservas | 2022/03/01 19:30 | Defensor Sporting - Reservas v Torque - Reservas | L | 2-3 |
| Uruguai - Liga de Reservas | 2022/02/14 19:30 | Defensor Sporting - Reservas v Liverpool Montevideo - Reservas | L | 1-2 |
| Uruguai - Liga de Reservas | 2021/12/07 19:00 | Defensor Sporting - Reservas v Juventud de Las Piedras - Reservas | L | 0-1 |
| Uruguai - Liga de Reservas | 2022/05/03 13:00 | Penarol - Reservas v Cerrito - Reservas | L | 1-0 |
| Uruguai - Liga de Reservas | 2022/04/18 18:30 | Atlético Fénix - Reservas v Cerrito - Reservas | L | 3-2 |
| Uruguai - Liga de Reservas | 2022/04/05 19:00 | Cerrito - Reservas v Liverpool Montevideo - Reservas | D | 0-0 |
| Uruguai - Liga de Reservas | 2022/03/21 19:00 | Cerrito - Reservas v Rentistas - Reservas | D | 2-2 |
| Uruguai - Liga de Reservas | 2022/03/15 13:30 | Club Atlético River Plate - Reservas v Cerrito - Reservas | L | 3-0 |
| Uruguai - Liga de Reservas | 2022/03/01 19:30 | Cerrito - Reservas v Deportivo Maldonado - Reservas | W | 2-1 |
| Uruguai - Liga de Reservas | 2022/02/22 19:30 | Boston River - Reservas v Cerrito - Reservas | W | 1-2 |
| Uruguai - Liga de Reservas | 2022/02/15 19:30 | Cerrito - Reservas v Danubio - Reservas | L | 1-3 |