Estádio: Caesars Superdome Round: 1
Home Manager: Eric Dooley Away Manager: Hue Jackson
| NCAAF | 2021/11/27 22:00 | Southern v Grambling State | W | 26-29 |
| NCAAF | 2021/04/17 18:30 | Grambling State v Southern | L | 7-49 |
| NCAAF | 2019/11/30 22:00 | Southern v Grambling State | L | 30-28 |
| NCAAF FCS | 2018/11/24 22:00 | Grambling State v Southern | L | 28-38 |
| NCAAF | 2017/11/25 22:00 | Grambling State v Southern | W | 30-21 |
| NCAAF | 2022/11/13 00:00 | Grambling State v Texas Southern Tigers | L | 7-41 |
| NCAAF | 2022/11/05 19:00 | Arkansas Pine Bluff v Grambling State | W | 10-36 |
| NCAAF | 2022/10/29 19:00 | Alcorn State v Grambling State | W | 6-35 |
| NCAAF | 2022/10/15 18:00 | Florida A&M v Grambling State | L | 20-16 |
| NCAAF | 2022/10/08 18:00 | Grambling State v Alabama | L | 31-37 |
| NCAAF | 2022/10/01 23:00 | Prairie View v Grambling State | L | 34-14 |
| NCAAF | 2022/09/24 18:00 | Grambling State v Bethune Cookman | L | 19-36 |
| NCAAF | 2022/09/17 18:00 | Grambling State v Jackson State | L | 24-66 |
| NCAAF | 2022/11/12 20:00 | Southern v Mississippi Valley State | W | 27-7 |
| NCAAF | 2022/11/05 22:00 | Southern v Florida A&M | L | 16-30 |
| NCAAF | 2022/10/29 18:00 | Southern v Jackson State | L | 0-35 |
| NCAAF | 2022/10/22 21:00 | Southern v Lynchburg Dragons | W | 51-7 |
| NCAAF | 2022/10/15 23:00 | Alcorn State v Southern | W | 17-21 |
| NCAAF | 2022/10/08 21:00 | Southern v Prairie View | W | 45-13 |
| NCAAF | 2022/10/01 23:00 | Arkansas Pine Bluff v Southern | W | 3-59 |
| NCAAF | 2022/09/17 21:00 | Southern v Texas Southern Tigers | L | 0-24 |