Estádio: Estádio Municipal Round: 1
Home Manager: Terry Sims Away Manager: Olive Pough
| NCAAF | 2021/10/02 17:30 | Bethune Cookman v South Carolina State | W | 35-42 |
| NCAAF | 2019/10/26 20:00 | South Carolina State v Bethune Cookman | W | 27-19 |
| NCAAF | 2018/10/13 18:00 | Bethune Cookman v South Carolina State | L | 28-26 |
| NCAAF | 2017/10/14 20:00 | Bethune Cookman v South Carolina State | L | 12-9 |
| NCAAF | 2022/09/01 23:00 | South Carolina State v Central Florida | L | 10-56 |
| NCAAF - Bowl Games | 2021/12/18 17:00 | South Carolina State v Jackson State | W | 31-10 |
| NCAAF | 2021/11/20 19:00 | South Carolina State v Norfolk State | W | 31-21 |
| NCAAF | 2021/11/13 18:30 | North Carolina A&T v South Carolina State | L | 27-17 |
| NCAAF | 2021/11/06 18:00 | Howard v South Carolina State | W | 12-15 |
| NCAAF | 2021/10/30 18:00 | South Carolina State v North Carolina Central | W | 27-24 |
| NCAAF | 2021/10/23 18:00 | South Carolina State v Delaware State | W | 13-7 |
| NCAAF | 2021/10/16 17:30 | Morgan State v South Carolina State | W | 14-37 |
| NCAAF | 2022/09/03 19:30 | Bethune Cookman v Miami Florida | L | 13-70 |
| NCAAF | 2021/11/20 20:30 | Florida A&M v Bethune Cookman | L | 46-21 |
| NCAAF | 2021/11/13 17:00 | Grambling State v Bethune Cookman | W | 14-31 |
| NCAAF | 2021/11/06 16:00 | Alcorn State v Bethune Cookman | W | 31-35 |
| NCAAF | 2021/10/23 18:00 | Bethune Cookman v Jackson State | L | 12-42 |
| NCAAF | 2021/10/16 17:00 | Prairie View v Bethune Cookman | L | 35-29 |
| NCAAF | 2021/10/09 20:00 | Mississippi Valley State v Bethune Cookman | L | 20-14 |
| NCAAF | 2021/10/02 17:30 | Bethune Cookman v South Carolina State | L | 35-42 |