[4] Santos Laguna 1-1 Club América [2] 2018-11-12 00:00
Estádio: Estádio Corona Round: 16
Juiz: Jorge Isaac Rojas Castillo Home Manager: Salvador Reyes Away Manager: Miguel Herrera
Head to Head
| México - Liga MX | 2018/05/14 00:00 | Club América v Santos Laguna | D | 2-2 |
| México - Liga MX | 2018/05/11 00:30 | Santos Laguna v Club América | W | 4-1 |
| México - Liga MX | 2018/04/29 02:00 | Club América v Santos Laguna | L | 1-0 |
| México - Liga MX | 2017/11/20 00:30 | Santos Laguna v Club América | L | 0-1 |
| Europa - Amigáveis | 2017/07/06 01:30 | Club América v Santos Laguna | L | 3-2 |
| México - Liga MX | 2017/04/24 00:00 | Santos Laguna v Club América | W | 2-1 |
| Taça do México | 2017/03/02 02:30 | Santos Laguna v Club América | W | 2-1 |
| Taça do México | 2017/01/19 02:30 | Club América v Santos Laguna | L | 3-2 |
Home History
| México - Liga MX | 2018/11/04 22:00 | Querétaro v Santos Laguna | L | 2-1 |
| México - Liga MX | 2018/10/27 00:00 | Santos Laguna v Monterrey | W | 1-0 |
| México - Liga MX | 2018/10/21 00:00 | Pachuca v Santos Laguna | D | 1-1 |
| México - Liga MX | 2018/10/06 00:00 | Santos Laguna v Atlas | W | 3-1 |
| México - Liga MX | 2018/09/30 02:00 | Necaxa v Santos Laguna | W | 0-1 |
| México - Liga MX | 2018/09/23 23:00 | Santos Laguna v Veracruz | D | 1-1 |
| México - Liga MX | 2018/09/16 21:00 | Santos Laguna v Club León | W | 3-0 |
| Mundo - Amigáveis de Clubes | 2018/09/05 23:41 | Charlotte Independence v Santos Laguna | W | 0-3 |
Away History
| México - Liga MX | 2018/11/04 01:00 | Club América v Toluca | D | 1-1 |
| México - Liga MX | 2018/10/28 02:00 | Cruz Azul v Club América | D | 0-0 |
| México - Liga MX | 2018/10/21 00:00 | Club América v Tijuana | W | 3-0 |
| México - Liga MX | 2018/10/07 00:00 | Tigres UANL v Club América | W | 2-3 |
| México - Liga MX | 2018/09/30 23:00 | Club América v Chivas Guadalajara | D | 1-1 |
| Taça do México | 2018/09/26 02:15 | Club América v Juárez FC | L | 10-11 |
| México - Liga MX | 2018/09/22 02:00 | Puebla v Club América | W | 2-3 |
| México - Liga MX | 2018/09/16 00:00 | Club América v Atlético Morelia | W | 2-1 |