[3] America de Cali 0-2 Cerro Porteño [3] 2021-04-22 02:00
Estádio: Estádio Alfonso Lopez Round: 1
Juiz: Fernando Echenique Home Manager: Juan Cruz Real Away Manager: Francisco Arce
Home History
| Colômbia - Primera A | 2021/04/18 20:30 | America de Cali v Deportes Tolima | W | 2-0 |
| Colômbia - Primera A | 2021/04/10 22:40 | Jaguares de Cordoba v America de Cali | D | 0-0 |
| Colômbia - Primera A | 2021/04/04 20:30 | America de Cali v La Equidad | L | 0-1 |
| Colômbia - Primera A | 2021/03/31 20:30 | America de Cali v Millonarios | W | 2-1 |
| Colômbia - Primera A | 2021/03/28 21:00 | Alianza Petrolera v America de Cali | W | 0-2 |
| Colômbia - Primera A | 2021/03/24 20:15 | America de Cali v Independiente Medellin | L | 1-2 |
| Colômbia - Primera A | 2021/03/21 01:00 | Once Caldas v America de Cali | D | 1-1 |
| Colômbia - Primera A | 2021/03/12 01:00 | Deportivo Cali v America de Cali | W | 0-2 |
Away History
| Paraguai - División Profesional | 2021/04/18 21:45 | Cerro Porteño v Club Libertad | L | 0-3 |
| Paraguai - División Profesional | 2021/04/11 22:15 | Sportivo Luqueño v Cerro Porteño | D | 3-3 |
| Paraguai - División Profesional | 2021/04/04 23:00 | Cerro Porteño v Club Sol de América | W | 1-0 |
| Paraguai - División Profesional | 2021/03/21 21:15 | Cerro Porteño v Club Guaraní | W | 2-1 |
| Paraguai - División Profesional | 2021/03/13 21:30 | 12 de Octubre v Cerro Porteño | W | 0-2 |
| Paraguai - División Profesional | 2021/03/09 23:45 | Cerro Porteño v River Plate Asuncion | W | 3-0 |
| Paraguai - División Profesional | 2021/03/06 21:15 | Club Nacional v Cerro Porteño | L | 2-0 |
| Paraguai - División Profesional | 2021/02/28 21:30 | Club Olimpia v Cerro Porteño | L | 2-0 |