| WTA - Luxemburgo | 10/12 16:20 | 45 | [261] Despina Papamichail v Marta Kostyuk [163] | 4-6,3-6 | |
| ITF - W25 Santa Margherita | 10/08 12:05 | 25 | Corinna Dentoni v Despina Papamichail | 3-6,6-0,6-0 | |
| ITF - W60 Valência | 09/24 09:00 | 54 | [263] Despina Papamichail v Guiomar MZD Reales [349] | 6-3,2-6,8-10 | |
| ITF - W60 Valência | 09/23 10:30 | 54 | Despina Papamichail v Jessica B Maneiro | 6-4,6-3 | |
| ITF - W25 Frýdek-Místek | 09/14 09:00 | 28 | Despina Papamichail v Ekaterine Gorgodze | 0-6,2-6 | |
| ITF - W25 Frýdek-Místek | 09/13 09:00 | 27 | [437] Vlada Koval v Despina Papamichail [276] | 5-7,6-7 | |
| ITF - W25 Frýdek-Místek | 09/12 09:00 | 26 | [451] Karolina Kubanova v Despina Papamichail [276] | 0-6,1-6 | |
| ITF - W25 Frýdek-Místek | 09/11 09:00 | 25 | Johana Markova v Despina Papamichail | 4-6,4-6 | |
| ITF - W60 Zagreb | 09/07 09:30 | 27 | [282] Despina Papamichail v Reka-Luca Jani [276] | 4-6,5-7 | |
| ITF - W60 Zagreb | 09/05 10:45 | 26 | [193] Martina Trevisan v Despina Papamichail [282] | 3-6,6-1,4-6 | |
| ITF - W60 Zagreb | 09/04 09:00 | 25 | [282] Despina Papamichail v Maryna Zanevska [275] | 6-4,7-5 | |
| ITF - W60 Zagreb | 09/02 08:00 | 54 | [282] Despina Papamichail v Yana Morderger [330] | 6-2,6-2 | |
| ITF - W60 Zagreb | 09/01 08:40 | 54 | Despina Papamichail v Iva Zelic | 6-0,6-1 | |
| ITF - W25 Viena | 08/29 11:55 | 26 | [282] Despina Papamichail v Laura Ioana Paar [237] | 2-6,0-6 | |
| ITF - W25 Viena | 08/27 10:00 | 25 | [282] Despina Papamichail v Andrea Lazaro Garcia [398] | 1-6,6-2,6-2 | |
| ITF - W25 LPD Gran Canária | 08/16 10:00 | 27 | Ana Sofia Sanchez v Despina Papamichail | 4-6,6-3,6-4 | |
| ITF - W25 LPD Gran Canária | 08/15 10:00 | 26 | Ana L De La Nuez v Despina Papamichail | 2-6,2-6 | |
| ITF - W25 LPD Gran Canária | 08/14 15:00 | 25 | Maria G Carrasco v Despina Papamichail | 4-6,7-5,3-6 | |
| ITF - W25 LPD Gran Canária | 08/09 10:00 | 27 | [294] Despina Papamichail v Leonie Kung [378] | 3-6,6-7 | |
| ITF - W25 LPD Gran Canária | 08/08 09:00 | 26 | [294] Despina Papamichail v Alba Carrillo Marin [489] | 5-7,6-3,7-6 | |
| ITF - W25 LPD Gran Canária | 08/07 09:00 | 25 | Despina Papamichail v Lucia Cortez Llorca | 6-4,4-6,6-1 | |
| ITF - W25 Aschaffenburg | 07/21 11:30 | 29 | [341] Jule Niemeier v Despina Papamichail [470] | 2-6,7-5,2-6 | |
| ITF - W25 Aschaffenburg | 07/20 15:50 | 28 | [470] Despina Papamichail v Katharina Hobgarski [208] | 2-6,6-4,6-2 | |
| ITF - W25 Aschaffenburg | 07/19 11:30 | 27 | Despina Papamichail v Ivana Popovic | 4-6,6-1,6-3 | |
| ITF - W25 Aschaffenburg | 07/18 11:00 | 26 | Despina Papamichail v Indy De Vroome | 5-7,6-3,6-4 | |
| ITF - W25 Aschaffenburg | 07/17 13:45 | 25 | [388] Irene Burillo Escorihuela v Despina Papamichail [470] | 6-1,4-6,0-6 | |
| ITF - W25 Getxo | 07/14 08:30 | 29 | [453] Despina Papamichail v Sandra Samir [499] | 6-2,6-4 | |
| ITF - W25 Getxo | 07/13 10:30 | 28 | [453] Despina Papamichail v Irene B Escorihuela [392] | 6-4,6-7,6-3 | |
| ITF - W25 Getxo | 07/12 11:00 | 27 | [258] Nadia Podoroska v Despina Papamichail [453] | 0-6,4-6 | |
| ITF - W25 Getxo | 07/11 09:00 | 26 | [453] Despina Papamichail v Lina Gjorcheska [372] | 7-5,6-3 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 93, achieved on 4 December 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 37 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 31–29 (as of May 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event by defeating Gabriela Cé, her first title above $25k level.
She made her WTA Tour main-draw debut 2021 at the WTA 500 event in Abu Dhabi.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
Later, she qualified for the Pan Pacific Open and defeated lucky loser Sakura Hosogi.