| ITF - W80 Valência | 09/23 10:30 | 26 | [160] Francesca Jones v Despina Papamichail [215] | 7-6,6-1 | |
| ITF - W80 Valência | 09/22 11:30 | 25 | [200] Diane Parry v Despina Papamichail [215] | 3-6,3-6 | |
| ITF - W80 Valência | 09/16 08:25 | 26 | [222] Despina Papamichail v Panna Udvardy [161] | 7-6,1-6,4-6 | |
| ITF - W80 Valência | 09/15 12:30 | 25 | [131] Ysaline Bonaventure v Despina Papamichail [222] | 4-6,2-6 | |
| ITF - W25 Saint-Palais-sur-Mer | 09/11 12:55 | 28 | [230] Despina Papamichail v Amandine Hesse [229] | 4-6,5-7 | |
| ITF - W25 Saint-Palais-sur-Mer | 09/10 12:30 | 27 | [397] Leolia Jeanjean v Despina Papamichail [230] | 1-6,4-6 | |
| ITF - W25 Saint-Palais-sur-Mer | 09/09 13:25 | 26 | Laia Petretic v Despina Papamichail | 4-6,2-6 | |
| ITF - W25 Saint-Palais-sur-Mer | 09/07 11:00 | 25 | [444] Magali Kempen v Despina Papamichail [230] | 3-6,2-6 | |
| Open dos EUA - Feminino | 08/26 16:35 | 15 | [229] Despina Papamichail v Dalma Galfi [152] | 6-7,1-6 | |
| Open dos EUA - Feminino | 08/24 22:20 | 14 | [120] Renata Zarazua v Despina Papamichail [229] | 5-7,6-7 | |
| ITF W60 San Bartolome De Tirajana | 08/11 08:30 | 25 | [226] Despina Papamichail v Barbara Gatica [349] | 3-6,6-7 | |
| ITF - W60 Grodzisk Mazowiecki | 07/30 09:00 | 27 | [185] Ekaterine Gorgodze v Despina Papamichail [227] | 6-3,6-0 | |
| ITF - W60 Grodzisk Mazowiecki | 07/29 10:05 | 26 | [371] Martyna Kubka v Despina Papamichail [227] | 3-6,4-6 | |
| ITF - W60 Grodzisk Mazowiecki | 07/28 10:00 | 25 | Andrea Gamiz v Despina Papamichail | 6-3,3-6,6-7 | |
| WTA - Palermo | 07/18 17:45 | 19 | [199] Despina Papamichail v Katharina Gerlach [225] | 4-6,6-2,5-7 | |
| WTA - Palermo | 07/17 19:25 | 14 | [199] Despina Papamichail v Dalila Spiteri [499] | 3-6,7-5,6-2 | |
| ITF - W60 Amstelveen | 07/09 10:00 | 27 | [282] Alexandra Cadantu v Despina Papamichail [227] | 3-6,6-3,6-4 | |
| ITF - W60 Amstelveen | 07/08 12:10 | 26 | [478] Andreea Prisacariu v Despina Papamichail [227] | 4-6,4-6 | |
| ITF - W60 Amstelveen | 07/07 09:55 | 25 | [255] Chloe Paquet v Despina Papamichail [227] | 6-2,4-6,3-6 | |
| ITF - W25 Wrocław | 07/01 13:10 | 26 | [437] Weronika Falkowska v Despina Papamichail [227] | 4-6,6-3,6-4 | |
| ITF - W25 Wrocław | 06/30 09:30 | 25 | Nikola Tomanova v Despina Papamichail | 3-6,3-6 | |
| ITF - W60 Charleston | 06/27 14:55 | 29 | [240] Gabriela Ce v Despina Papamichail [227] | 6-1,3-6,3-6 | |
| ITF - W60 Charleston | 06/26 13:55 | 28 | [372] Fernanda Contreras Gomez v Despina Papamichail [261] | 2-6,2-6 | |
| ITF - W60 Charleston | 06/25 13:55 | 27 | [300] Alexa Glatch v Despina Papamichail [261] | 6-4,0-6,4-6 | |
| ITF - W60 Charleston | 06/24 16:40 | 26 | Charlotte Chavatipon v Despina Papamichail | 3-6,3-6 | |
| ITF - W60 Charleston | 06/23 13:30 | 25 | [368] Aldila Sutjiadi v Despina Papamichail [261] | 6-2,3-6,1-6 | |
| ITF - W25 Jönköping | 06/14 12:25 | 25 | [395] Camilla Rosatello v Despina Papamichail [258] | 7-5,6-3 | |
| ITF - W25 Grado | 06/02 17:45 | 26 | [106] Liudmila Samsonova v Despina Papamichail [269] | 6-0,6-4 | |
| ITF - W25 Grado | 06/01 10:25 | 25 | Melania Delai v Despina Papamichail | 6-7,5-7 | |
| WTA - Estrasburgo | 05/23 12:15 | 19 | Despina Papamichail v Maryna Zanevska | 6-4,2-6,5-7 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993 in Preveza) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 109, achieved on 18 September 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 36 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 25–28 (as of January 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event, by defeating Gabriela Cé. It was her first title above $25k level.
She made her main-draw WTA Tour singles debut at the WTA 500 2021 Abu Dhabi Open.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
She qualified for the 2023 Toray Pan Pacific Open and defeated lucky loser Sakura Hosogi.